Effect of Functionalized CdSSe Quantum Dots in the CYP450 Activity of HEPG2 Cells

Quantum dots (QDs) have different properties: high electron density, magnetic moment, phosphorescence, photoluminescence (fluorescence), and strong optical absorption. The layer or ligands on the QDs surface has a vital role because they allow stabilization practical uses matrixes. Ligand exchange is commonly carried out methodology to incorporate functional groups that alter solubility, introduce transfer partners, integrate biological receptors, improve properties of surface. CdSSe were synthesized using microwave system thioglycolic acid (TGA) as sulfur source cover agent. TGA ligand was interchanged with cysteine (Cys), glutamic (GA), glutathione (GTO), glutaraldehyde (GLT), lysine (Lys). viability response CYP1A1, CYP1A2, CYP3A4 isoenzymes directly measured in HEP-G2 cells after exposure CdSSe-TGA, CdSSe-Cys, CdSSe-GA, CdSSe-GTO, CdSSe-GLT, CdSSe-Lys. CdSSe-GTO (10 mg/L) decrease by around 65%. cytochrome based organic QDs. Changes CYP 1A1 could be related carcinogenic xenobiotics. Fluorescence microscopy shows inside HEPG2 cells. results confirm apoptosis necrosis are principal mechanisms decreased viability.